There was no denying that Queen Elizabeth II’s message to her grandson Prince Harry and his wife Meghan Markle had a line that stood out.

Two days after the Duke and Duchess of Sussex’s bombshell interview with Oprah Winfrey aired, Buckingham Palace released a 61-word statement on behalf of the reigning monarch.

"The whole family is saddened to learn the full extent of how challenging the last few years have been for Harry and Meghan," said a statement from the palace provided to Fox News. "The issues raised, particularly that of race, are concerning.  While some recollections may vary, they are taken very seriously and will be addressed by the family privately."

"Harry, Meghan and Archie will always be much loved family members," the statement concluded.

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This image provided by Harpo Productions shows Prince Harry, from left, and Meghan, The Duchess of Sussex, in conversation with Oprah Winfrey. (AP)

Representatives for the Duke and Duchess of Sussex had no comment when reached by Fox News.

On Thursday, a royal insider told People magazine that the "some recollections may vary" remark was an "underlying jab" that indicates dissent among the royal family at some of the claims made during the televised sit-down.

"There was anger," a palace source told the outlet for this week’s cover story. "There was genuinely mixed emotions and deep sorrow and shock there too."

On March 7, CBS aired a two-hour interview that the Duke and Duchess of Sussex did with Winfrey, 67. During the televised sit-down, Harry, 36, revealed that his relationships with Prince Charles, 72, and Prince William, 38, have ruptured.

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FILE - In this July 23, 2019 file photo, Britain's Prince Harry delivers a speech as he attends Dr Jane Goodall's Roots & Shoots Global Leadership Meeting at St. George's House, Windsor Castle in England. The eco-minded Prince Harry announces a massive travel sustainability initiative in partnership with key service providers that’s aimed at bettering the practices of the global industry amid an ever-increasing number of travelers. The Duke of Sussex announced Travalyst at a news conference Tuesday, Sept. 3, in Amsterdam, a city hit hard by over-tourism. He was joined by his partners, including Visa, TripAdvisor and Booking.com.(AP Photo/Kirsty Wigglesworth, Pool)

Prince Harry admitted to Oprah Winfrey that his relationships with Prince Charles and Prince William have ruptured. (AP)

Markle, 39, described feeling so isolated and miserable inside the royal family that she had suicidal thoughts. The Duchess of Sussex also alleged that a member of the royal family had "concerns" about the color of her unborn child’s skin.

The family member was not Elizabeth, 94, or Prince Philip, according to Harry, sparking a flurry of speculation about who it could be.

Harry told Winfrey the royal family cut him off financially at the start of 2020 after announcing plans to step back from his roles. However, he was able to afford security for his family because of the money his late mother Princess Diana left behind.

As for Charles and William, Harry admitted his relationships with the senior royals are still strained.

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FILE - In this Nov. 11, 2018 file photo, Meghan Markle, Duchess of Sussex, attends the Remembrance Sunday ceremony at the Cenotaph in London. Meghan Markle’s father appealed to his daughter to call him, saying on Monday, Dec. 17, 2018, that they hadn’t been in touch since her wedding to Prince Harry in May. (AP Photo/Alastair Grant, File)

Meghan Markle detailed her struggles as a member of the British royal family. (AP)

"It’s a sad state of affairs because William and Harry could have been so brilliant [as a team]," another source told the outlet. "To think of what they could have achieved together is almost heartbreaking."

Shortly before the interview, the U.K. Times reported that Markle faced a bullying complaint made by one of her close advisers during her time as a working royal at Kensington Palace. Her team strongly denied the allegations.

"The Duchess is saddened by this latest attack on her character, particularly as someone who has been the target of bullying herself and is deeply committed to supporting those who have experienced pain and trauma," a spokesperson told Fox News in a statement.

According to People, the palace has set up an inquiry and will likely bring in an outside law firm to assist.

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Shortly after the televised tell-all, Buckingham Palace released a short statement on behalf of Queen Elizabeth II, Prince Harry's grandmother. (Getty Images)

"For [some staffers] there was real stress and real trauma," one source alleged to the outlet. "These are real people and there is a human toll."

After Harry and Markle married in May 2018 at Windsor Castle, the royal family seemed to welcome the Duchess of Sussex, a glamorous former TV star. The pair were seen as providing a fresh young face for the monarchy of an increasingly multicultural nation.

It didn’t take long for the fairytale to unravel.

The couple stepped away from royal duties last year and eventually settled in California, saying they wanted to escape racist coverage and unwanted intrusions on their privacy by the British media.

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Meghan Markle and Prince Harry currently reside in California with their son Archie. (Getty)

During the interview, the duke and duchess shared they are expecting a girl due this summer.

The Associated Press contributed to this report.