It happened just after 8 p.m. at the intersection of Eastern Parkway and Schenectady Avenue.
Police said a marked van collided with an unidentified adult male.
Emergency responders rushed him to the nearby Kings County Hospital, where he was pronounced deceased, according to the NYPD.
Police said they had no reports that anyone else was injured in the incident. The investigation was ongoing, and they noted that the details were preliminary.
Several videos shared to the Citizen App showed police tape, fire trucks, numerous police vehicles and an ambulance at the scene with flashing lights.
One showed a police van stopped on the median and several people standing in front. It was not immediately clear whether that had been the one involved in the crash.
In the same video, a group of unseen people can be overheard discussing the incident.
"You heard it right?" a man asks.
A woman replies that she had just come off the subway and "saw the f---ing shoes flew off."
This is a developing story.