The suspects, both wearing dark hoodies, entered the store at Madison Avenue and 62nd Street at around 11:35 a.m. and started grabbing items off the shelves, an NYPD spokesperson told Fox News.
Police said the pair then ran out of the store and got into a blue Jeep SUV with North Carolina license plates, before fleeing north on Madison Avenue.
The thieves got away with 12 handbags worth about $26,000, according to investigators.
Police told Fox News the investigation is ongoing and no arrests have been made. No injuries were reported.
It was not immediately clear for how long the thieves were inside the store or how many people were there at the time of the robbery.