Five teens, all between ages 15 and 17, and one adult man were shot at the corner of Canal Boulevard and City Park Avenue around 10:30 p.m., according to FOX 8 and NOLA.com.
The five wounded victims were taken to a hospital in unknown condition. The sixth victim was pronounced dead at the scene.
The New Orleans Police Department has not released any details on potential suspects or a motive, NOLA.com reported.
Another gunshot victim was found in a car in the New Orleans East neighborhood two hours earlier. Police have not reported any connection in the killings.
The investigation is ongoing.