Fort Worth, TX – J.R. Cadot's double-double of 15 points and 64 win over 18th-ranked New Mexico on Saturday.
Cadot was one of six TCU players to reach double-digits in scoring.
Hank Thorns provided 14 points and nine assists for the Horned Frogs (17-11, 7-5 MWC), who pushed their home winning streak to eight games.
Garlon Green added 13 points, Craig Williams 12, Amric Fields 11 and Kyan Anderson 10.
TCU posted its first victory over the Lobos since January 15, 2008, snapping an eight-game losing streak in the series.
A.J. Hardeman had 15 points to pace New Mexico (22-6, 8-4), which suffered its second straight loss to fall into a tie with UNLV for first place in the conference standings.