Appearing on "Outnumbered" with hosts Melissa Francis and Harris Faulkner, Lesko said it is a "sad day" for the American people.
"Now...I think this process has been a sham from the start," she said. "And, if I was a betting woman, I would've bet back in January of this year when Democrats took control of the House that they were going to impeach the president of the United States. And, sure enough, they did."
"They didn't even have a crime; they couldn't even name a crime that the president did and that's why they have these two very vague articles of impeachment. And it really, really, sets the bar low for future articles of impeachment, so just about anybody for any reason can be impeached in the future," the congresswoman explained.
"Is there a sense that anyone on either side is going to cross party lines?" asked Francis.
"I don't think there's going to be one single Republican that votes for impeachment and I do think we are going to get Democrats that vote with Republicans against impeachment," Lesko predicted. "It's just a matter of how many and we won't know till the vote actually takes place."
"I mean, I feel kind of bad for the Democrat members. They were elected in districts that Trump won. So Nancy Pelosi is really putting these members on the line. They are really risking that they are going to lose the majority, and I think they are," she added.
Trump, in a Tweet, echoed Lesko's comments about the process being "rigged."
President Trump called House Speaker Nancy Pelosi, D-Calif., a "liar" and accused Democrats of trivializing an impeachment process that should only be used "in an emergency," in his first comments after House Democrats advanced articles of impeachment against him.
"It's a scam. It's something that shouldn't be allowed," Trump said in the Oval Office Friday. "And it's a very bad thing for our country and you're trivializing impeachment. And I tell you what, someday there will be a Democrat president, and there will be a Republican House."
"And I suspect they're going to remember it," he said. "Because [that's what happens] when you use impeachment for absolutely nothing other than to try and get political gain."
Fox News' Marisa Schultz contributed to this report.