The brother-sister duo made the announcement during an appearance on "Good Morning America" on Thursday.
“It’s been rumored that we’re bringing Donny & Marie to an end here in Las Vegas,” Donny, 61, told the outlet. “And we’re here to say it’s official.”
“We have been through so much the last 11 years. Her particularly,” Donny went on to say about Marie, 59.
“And she gets on stage and she’s such a professional," he gushed. "She does a great job. I’m gonna miss this a lot… There’s a bond here that will never be broken.”
Their final performance at the Flamingo Las Vegas is scheduled for Nov. 16.
According to the casino, the two launched their residency back in September 2008, planning for just a six-week concert engagement. However, the residency was extended again and again, marking a decade of performances last year.
Despite ending their long-time show, Donny hinted that the duo will still continue to perform in some way.
“It's the end of the Donny & Marie show, it's not the end of Donny and Marie,” he said.
The Associated Press contributed to this report.