New York Yankees pitcher Gerrit Cole is apparently not a Billy Crystal fan – at least not on Friday.

The four-time MLB All-Star appeared visibly frustrated during Friday's Opening Day festivities when the start of the game against the Boston Red Sox was delayed by four minutes as actor and director Billy Crystal took to the field to throw out the ceremonial first pitch.

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"Let’s go! Let’s go!" Cole could be seen yelling from the dugout.

Cole opened the game with a four-pitch walk and the Red Sox led 3-0 on Rafael Devers' two-run homer and J.D. Martinez's RBI double before Cole got a single out. 

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"Tough settling in," he said after the game, via Yahoo Sports. "Obviously, the first four pitches were not really competitive, and then honestly got burned on a couple pretty good fastball locations in the first. They put some pretty great swings on it. Fortunately, we were able to settle in after that and give us a chance to win."

New York Yankees Gerrit Cole

Gerrit Cole #45 of the New York Yankees reacts in the first inning against the Boston Red Sox at Yankee Stadium on April 8, 2022, in New York City.  (Mike Stobe/Getty Images)

When asked about the four-minute delay, Cole explained his frustrations. 

"That was an unforeseen challenge. Festivities got a little away from the schedule."

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Perhaps it was opening day jitters. 

Yankees Gerrit Cole Billy Crystal

Actor Billy Crystal throws out the first pitch prior to the start of the game between the New York Yankees and the Boston Red Sox at Yankee Stadium on April 8, 2022, in New York City.

Josh Donaldson's walk-off win in the 11th inning – New York’s first on opening day since 1957, lifted the Yankees over the Boston Red Sox 6-5.

The Associated Press contributed to this report.