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Flushing Meadows, NY (SportsNetwork.com) - Five-time champion Serena Williams and two-time runner-up Victoria Azarenka eased into the third round, while eighth seed Ana Ivanovic was a second-round upset victim Thursday at the U.S. Open.

The world No. 1 and two-time reigning U.S. Open titlist Williams flattened fellow American Vania King 6-1, 6-0 in 56 minutes at Ashe Stadium on another sun-drenched day in New York.

Williams' third-round opponent will be a third straight compatriot, Varvara Lepchenko, who eased past German Mona Barthel 6-4, 6-0. The 17-time Grand Slam champ Williams whipped fellow countrywoman Taylor Townsend on Tuesday.

Meanwhile, 42nd-ranked big-hitting tall Czech Karolina Pliskova stunned the former world No. 1 from Serbia Ivanovic 7-5, 6-4, while the 16th-seeded former top-ranked star Azarenka handled American Christina McHale 6-3, 6-2 on the grounds at the USTA Billie Jean King National Tennis Center.

Having her best season since 2008, Ivanovic is a former French Open champ who has only ever reach one U.S. Open quarterfinal. She joined fourth-seeded Agnieszka Radwanska as another top-10 second-round upset victim over the last two days.

Ivanovic leads the WTA with 48 match wins this season.

The two-time Australian Open titlist Azarenka appeared in the last two U.S. Open finals, losing to the incomparable Williams both times. The Belarusian star is still on the mend after missing three months of action this year due to a foot injury.

"Christina started really well, not missing a ball, and I felt like I was always on my back foot," Azarenka said in a post-match interview after beating McHale. "I tried to fight and got my momentum, and felt like I started to do what I should have been doing in the beginning."

Up next for Azarenka will be Russian Elena Vesnina, who slipped past New Zealand's Marina Erakovic 7-5, 2-6, 6-4.

Eleventh-seeded Italian Flavia Pennetta dismissed American Shelby Rogers 6-4, 6-3 to set-up a match with another American, Nicole Gibbs, who upset 23rd- seeded Russian Anastasia Pavlyuchenkova 6-4, 6-7 (6-8), 6-3, while 15th-seeded nifty Spaniard Carla Suarez Navarro spanked American Coco Vandeweghe 6-3, 6-3.

In other action involving seeds, No. 29 Aussie Casey Dellacqua overcame China's Wang Qiang 4-6, 6-4, 6-2 and No. 30 Czech Barbora Zahlavova Strycova came back to best Romanian Monica Niculescu 4-6, 6-4, 6-2.