Deirdre Naughton hit five 3-pointers, matching her total for the season, and finished with a season-high 19 points to help No. 10 DePaul beat Syracuse 77-61 Tuesday night.

DePaul (22-3, 9-1 Big East), coming off an 89-66 loss at No. 2 Connecticut, was an impressive 13 of 23 (56.5 percent) from beyond the arc as the Blue Demons tied No. 8 Notre Dame for second in the conference.

After consecutive road losses to Notre Dame and Rutgers, Syracuse (16-7, 4-6 Big East) lost for only the second time in 16 home games. DePaul leads the series with Syracuse 5-1, 3-0 on the road, since joining the league in the 2005-06 season.

Naughton hit three from beyond the arc and Sam Quigley drained another in less than 6 minutes to key a game-breaking 18-7 second-half run. Naughton finished it with a 3 to give DePaul a 66-51 lead with 9:23 left.

Keisha Hampton added 18 points and seven rebounds and Anna Martin had 11 points for DePaul, which limited Syracuse to 38.6 percent shooting (22 of 57), 4 of 17 (23.5 percent) on 3-pointers.

Carmen Tyson-Thomas led Syracuse with 16 points and 13 rebounds, Iasia Hemingway added 14 points, and Shakeya Leary had 13 points.

The last time these teams met the Orange had three players in double figures but were undone by 24 turnovers and 21 offensive rebounds by the Blue Demons.

This time the Orange's 2-3 zone was victimized repeatedly by the hot-shooting Blue Demons, who were 29 of 57 (50.9 percent), kept making an extra pass to leave shooters open, and finished with 22 assists.

DePaul jumped to an early lead behind Hampton, who hit three 3s in the first seven minutes as the Blue Demons moved the ball nicely around the perimeter to create open looks against the zone. Hampton's runner at 11:49 gave her 11 points and the Blue Demons a 20-11 lead.

Not flustered by DePaul's press, the Orange rallied behind Leary, who had six points to key a 15-4 run. Leary's layup off a feed from Elashier Hall gave Syracuse a 23-20 lead at 7:38 of the opening half, which had four ties and seven lead changes.

Naughton hit a 3-pointer to put the Blue Demons back in front to stay, 34-33 with 3:12 to go and followed with a pullup jumper on the break.

China Threatt hit DePaul's seventh and last 3 of the opening period with 28 seconds to play to give the Blue Demons a 39-35 halftime lead.

DePaul's other losses were at Purdue, 67-58, in November, and at Arizona State, 79-66, in December, five days after stunning then-No. 2 Stanford 91-71.