"It has been my distinct honor to serve as Chairman of the Republican Party of Texas. I pray Godspeed for this governing body," he said in a release, according to FOX 7 in Austin.
He joked he might run for "dog catcher" before telling reporters he was looking at a statewide office or even a congressional run.
"There’s a guy in Texas 32 I really don't care for being my congressional representative," he said, referring to U.S. Rep. Colin Allred, a Democrat.
West – a 60-year-old Atlanta native who represented Florida's 22nd Congressional District from 2011 to 2013 before moving to Texas – has said he may challenge Texas Republican Gov. Greg Abbott in the upcoming primary, according to FOX 7.
West has been a frequent critic of Abbott’s handling of the coronavirus pandemic.
Travis County GOP Chairman Matt Mackowiak in a statement slammed West over his decision to resign.
"It is now clear that Allen West’s entire tenure as Texas GOP Chair was intended to do only what many suspected: provide him a platform for his political future, not an opportunity to build the party."
West took over the top position less than a year ago, according to the Texas Tribune.
But West said candidates have a window of opportunity to run for office, adding he planned to resign to avoid a conflict of interest.
He had a combative tenure during which he challenged the party's top leaders, including leading a protest outside Abbott's home.
West's resignation will take effect in July after a successor is chosen, according to FOX 7.
The Associated Press contributed to this report.