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Jimmy Kimmel slammed Democratic New York City Mayor Bill de Blasio for not supporting the New York Yankees, despite the fact that they are one victory away from bringing a World Series to the Bronx.

“What’s the deal with your mayor, de Blasio? Is there something wrong with this brain?”

The “Jimmy Kimmel Live” host then played a clip showing how the mayor “celebrates” the success of his city’s baseball team. A local news anchor reported that de Blasio is “such a die-hard Red Sox fan” that he said it would be “physically impossible” for him to support the Yankees, despite the financial and morale boosts that would come with the Fall Classic being played in the city he is expected to oversee.

“I mean I give him credit for honesty, but that might be the stupidest f--king thing I’ve ever heard anybody say,” Kimmel said.

De Blasio is a Boston Red Sox fan and Kimmel’s Brooklyn crowd booed when the late-night host mentioned that New Yorkers voted for him anyway.

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New York City Mayor Bill De Blasio delivers remarks on the third day of the Democratic National Convention on July 27, 2016 in Philadelphia. (Getty)

“It’s like I don’t even know you anymore,” Kimmel said. “I just want to say congratulations to Bill de Blasio on his final term as mayor of the city of New York.”

ABC’s late-night star was a fairly non-political talk show host for the first 10-plus years of the show's run. That all changed in early 2017 when Kimmel detailed the open-heart surgery his newborn son, William, had to undergo. He explained that many children wouldn’t have the opportunity to survive without the Affordable Care Act, and emerged as an outspoken opponent of the Republican Congress’ attempt to undo it.

The ABC host recently said he “probably wouldn't want to have a conversation” with conservatives when asked if he was afraid of losing right-leaning viewers.

“Three years ago, I was equally liked by Republicans and Democrats. And, then, Republican numbers went way down, like thirty percent, or whatever. And you know, as a talk show host, that's not ideal, but I would do it again in a heartbeat,” he said on “CBS Sunday Morning.”

Kimmel’s shots at De Blasio prove he isn’t opposed to attacking Democrats, although he chose an easy target in the mayor of New York City.