Siena, Italy – AC Milan has four games remaining in its Serie A campaign to close the three-point gap between itself and leaders Juventus.
And Sunday's trip to Siena could present a potential stumbling block for manager Massimo Allegri's men, who have won only twice in their last five games to fall three points behind Juve.
Siena has tasted defeat just once in six games, meaning Milan had better bring its focus to the Artemio Franchi.
Juventus is in the midst of its best run of form of the season having won seven straight Serie A matches, and the club will expect to extend that streak with a visit to second-from-the-bottom Novara.
The hosts look likely to be relegated as they face an eight-point deficit over the final four games to avoid the drop.
The race for the third and final Champions League spot will take another twist on Sunday as third-place Lazio visits fifth-place Udinese with three points separating the two sides.
Lazio is in need of a good result having taken just one point from its last three games, while Udinese is in the same position having lost two of its last three contests, including a 3-1 setback at home against Inter Milan on Wednesday.
Napoli sits one point back of Lazio in fourth place and has just recently snapped out of a funk of its own. A three-game losing skid threatened the drop the club out of the Champions League race, but it has been followed by back-to- back wins to revive those aspirations.
The club will visit the Italian capital on Saturday to tangle with a Roma side that has seen its own Champions League hopes threatened after a run of three defeats in four games.
Roma is still just five points adrift of Lazio, while Inter Milan's current five-game unbeaten streak has dragged the club back into the discussion with the Nerazzurri only three points from third place.
Inter will be expected to beat last-place Cesena at the San Siro on Sunday, while the relegation fight heats up as well with 17th-place Genoa entering the weekend one point above 18th-place Lecce.
Genoa will visit Bologna in search of its first win in 14 games, while Lecce hosts Parma.
The other two matches on Saturday feature Cagliari hosting Chievo and Catania traveling to Palermo while Fiorentina invades Atalanta on Sunday.