Chicago, IL – Fausto Carmona pitched into the ninth inning to 1, in the second game series.
Carmona (6-12) allowed one run on four hits and three walks in 8 1/3 innings. He also struck out six in his first winning decision since July 18.
With the win, Cleveland increased its lead over Chicago for second place in the AL Central to a game and a half. The Indians still sit two games back of first-place Detroit.
Chris Perez recorded the final two outs of the game to earn his 26th save of the year and the Indians' seventh win in 11 contests.
Mark Buehrle (10-6) allowed four runs on 12 hits and two walks in 7 1/3 innings. It was the first time in 19 starts that Buehrle allowed more than three runs, keeping him tied with Frank Smith (1909) for the longest single-season streak in White Sox history with 18.
After recording 22 hits in Tuesday's, 8-7, 14th inning victory over Cleveland, Chicago could only muster four hits as the Sox had their three-game win streak snapped.