Buehrle's latest loss came on Thursday in Kansas City, as he was hit for seven runs (six earned) and a career-high 15 hits in 6 1/3 frames, dropping him to 11-9 on the year to go along with a 3.74 earned run average.
"I think as a starting pitcher you always know you're going to have some rough outings over the course of 30 starts," Buehrle said. "I went so many starts in a row doing good that it's kind of almost, something's going to happen where you're going to have a couple bad starts."
Over the course of the losing streak he has surrendered 20 earned runs in just 15 1/3 innings. But, as bad as he has been of late he is still only 7 2/3 innings shy of posting his 11th straight season with at least 200 innings, 30 starts and double-digit victories.
Buehrle has faced the Tribe 46 times (45 starts) and is 14-17 against them with a 4.81 ERA.
Cleveland will counter with righty Ubaldo Jimenez, who has won his last two starts. Jimenez improved to 4-2 with Cleveland on Friday in Minnesota, as he held the Twins to three runs (one earned) and five hits in 6 1/3 innings.
Jimenez is 1-0 in three starts versus the White Sox with a 4.08 ERA.
These teams split a day/night doubleheader on Tuesday, as Cleveland claimed a 4-3 win the first game before Chicago pulled out a 5-4 win in the nightcap.
Travis Hafner, Asdrubal Cabrera and Kosuke Fukudome homered to power the Indians in the first game, while Gordon Beckham posted three doubles, an RBI and a run scored to lead the White Sox in game two.
"It was one of those days I've searching for," Beckham said. "I'm glad we came back and won."
Chicago has won 10 of its 16 matchups with the Indians this season.