Fontvieille, Monaco – Reigning European champion and four- time winner AC Milan were placed into Group H 12 Champions League.
While Barca and AC Milan were placed with Belarus side BATE and Czech Republic side Viktoria Plzen for the two knockout round spots from the group, Group A - highlighted by Bayern Munich - is the clear "Group of Death."
Four-time winner Bayern, which will host the 2012 final, was drawn along with Villarreal, Manchester City and Napoli. The group is the only one featuring a club from each of Europe's top leagues.
Three-time winner Inter Milan, which last won in 2010, was placed into Group B along with CSKA Moscow, Lille and Trabzonspor.
Three-time winner Manchester United, which has reached three of the last four finals, is in Group C along with two-time winner Benfica, Basel and Otelul.
Record nine-time champion Real Madrid highlights Group C, which also includes Lyon, four-time winner Ajax and Dinamo Zagreb.
Chelsea, which lost the 2008 final to Manchester United in penalties, slotted into Group E, along with two-time runner-up Valencia, one-time runner-up Bayer Leverkusen and Genk.
Arsenal secured its passage into group play on Wednesday, and is atop Group F, which includes one-time winners Marseille and Borussia Dortmund, which won in 1997 when the final was in Munich, and Olympiacos.
Two-time winner FC Porto was placed in Group G, along with Shakhtar Donetsk, Zenit and APOEL.