2026 NFL Odds Week 1: Lines, Spreads, Results For All 16 Games

Headlined by a Sept. 9 Super Bowl rematch between the Seahawks and Patriots, as well as the NFL’s first-ever game in Australia between the Rams and 49ers, Week 1 is absolutely loaded.

Here are the lines for every Week 1 matchup at bet365 Sportsbook as of Sept. 11. 

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Patriots 10, Seahawks 13

Spread: Seahawks -3.5 (NE covers)
O/U: 44.5 (Under hits)

49ers 27, Rams 7

Spread: Rams -3.5 (SF covers)
O/U: 48.5 (Under hits)

Falcons @ Steelers

Spread: Steelers -5.5
Moneyline: Steelers -245, Falcons +200
O/U: 41.5

Ravens @ Colts

Spread: Ravens -3.5
Moneyline: Ravens -180, Colts +150
O/U: 47.5

Bills @ Texans

Spread: Bills -1.5
Moneyline: Bills -120, Texans +100
O/U: 44.5

Bears @ Panthers

Spread: Bears -3.5
Moneyline: Bears -170, Panthers +145
O/U: 47.5

Browns @ Jaguars 

Spread: Jaguars -8.5
Moneyline: Jaguars -425, Browns +325
O/U: 40.5

Saints @ Lions

Spread: Lions -6.5
Moneyline: Lions -330, Saints +265
O/U: 49.5

Jets @ Titans 

Spread: Titans -1.5
Moneyline: Titans -120, Jets +100
O/U: 38.5

Buccaneers @ Bengals 

Spread: Bengals -3.5
Moneyline: Bengals -200, Buccaneers +165
O/U: 50.5

Cardinals @ Chargers

Spread: Chargers -9.5
Moneyline: Chargers -500, Cardinals +375
O/U: 47.5

Packers @ Vikings

Spread: Vikings -1.5
Moneyline: Vikings -125, Packers +105
O/U: 46.5

Dolphins @ Raiders 

Spread: Raiders -3.5
Moneyline: Raiders -170, Dolphins +145
O/U: 40.5

Commanders @ Eagles 

Spread: Eagles -5.5
Moneyline: Eagles -240, Commanders +195
O/U: 44.5

Cowboys @ Giants

Spread: Cowboys -2.5
Moneyline: Cowboys -160, Giants +135
O/U: 48.5

Broncos @ Chiefs

Spread: Chiefs -2.5
Moneyline: Chiefs -150, Broncos +125
O/U: 43.5