Romo was limited in practice after slamming his right hand on the helmet of Eagles defensive end Jason Babin on Dallas' first possession last Saturday.
The winner of tonight's game will capture the NFC East title and earn a No. 4 seed, while the loser will be eliminated from playoff contention.
Giants tight end Jake Ballard was out due to a knee injury. Defensive end Osi Umenyiora, who hasn't played since November 28 against New Orleans due to an ankle injury, was active for New York.