Eugenie Bouchard is making another deep run at a Grand Slam after reaching the Wimbledon quarterfinals by beating the player who upset Serena Williams.

The 13th-seeded Canadian was down 5-3 in the second set but won the last four games to defeat France's Eugenie Bouchard 7-6 (5), 7-5 in Monday's opening match on Centre Court.

Bouchard's victory set up a potential quarterfinal duel with Maria Sharapova, the former Wimbledon champion who beat her in the semifinals en route to the French Open title last month.

"This is what I've worked so hard for, to be in the quarters at Wimbledon," Bouchard said. "But I want to go another step. I want to keep going."

Bouchard, the only woman to reach the semifinals this year at both the Australian Open and French Open, became the first Canadian to reach the quarterfinals at Wimbledon since the Open era began in 1968.

"Another little historic thing for Canada," she said. "That's cool. I hope I can go further."

While Canada is making a breakthrough, with Milos Raonic playing in the men's fourth round Tuesday, American tennis was left with no player — man or woman — in the draw after John Isner lost and Madison Keys pulled out with an injury.

It's the first time since 1911 that no American men or women have reached the round of 16 at Wimbledon.

"Didn't know that," Isner said after losing a third-round match to Feliciano Lopez in four sets. "Don't really care either."

Most of the Bouchard-Cornet match was played under the Centre Court roof after rain stopped play with the Frenchwoman up 3-2 in the first set.

"Finally, I got to play under the very famous roof," Bouchard said. "Happy for that experience."

Cornet was coming off a three-set win over the top-seeded and five-time champion Williams in the third round on Saturday, but couldn't hold off the aggressive Bouchard.

The first man to reach the quarterfinals was 26th-seeded Marin Cilic of Croatia, who followed up his third-round win over 2010 finalist Tomas Berdych by beating Jeremy Chardy 7-6 (8) 6-4, 6-4. Cilic will next play either top-seeded Novak Djokovic or Jo-Wilfried Tsonga.

The ninth-seeded Isner hit 52 aces but fell to 19th-seeded Lopez 6-7 (8), 7-6 (6), 7-6 (3), 7-5. Lopez earned the only service break of the match in the next-to-last game with a cross-court backhand passing winner. It was the only time Isner was broken during his three matches this year at the All England Club.

A three-time quarterfinalist at Wimbledon, Lopez will play Australian Open champion Stan Wawrinka next.

No. 5 Wawrinka beat Denis Istomin of Uzbekistan, 6-3, 6-3, 6-4 in a third-round match. Also reaching the fourth round was No. 10 Kei Nishikori, who downed Simone Bolelli of Italy, 3-6, 6-3, 4-6, 7-6 (4), 6-4 in a match that had been suspended at 3-3 in the fifth set Saturday.

The 19-year-old Keys withdrew from her uncompleted third-round match against Yaroslava Shvedova because of a strained left thigh. The match had been suspended by darkness on Saturday, with Kazakhstan player leading 7-6 (7), 6-6.

"I came in this morning and I had lots of tape on and I tried," the 30th-ranked Keys said. "I had so much tape on me I could barely walk. It just wasn't happening."

Among the women reaching the quarterfinals were three Czech players — 2011 champion Petra Kvitova, Lucie Safarova and unseeded Barbora Zahlavova Strycova.

The sixth-seeded Kvitova was a 6-3, 6-2 winner over Peng Shuai; No. 23 Safarova coasted to a 6-0, 6-2 win over 175th-ranked qualifier Tereza Smitkova — another Czech — and Zahlavova Strycova finally converted on her sixth match point to down No. 16 Caroline Wozniacki 6-2, 7-5.

Zahlavova Strycova, who has reached her first Grand Slam quarterfinal, served a six-month doping ban until April 2013 after testing positive for the stimulant sibutramine. She said Monday that she had considered quitting the sport during the suspension.

"I didn't want to come back and play again and compete," she said. "But it was just a short period of time. Like one month I was thinking like this. Then I was, 'Yeah, what I'm going to do?' I really like it. I love the sport. And then I didn't ask myself anymore."

Last year's Wimbledon runner-up, the 19th-seeded Sabine Lisicki of Germany, reached the fourth round by beating 2008 French Open champion and 11th-seeded Ana Ivanovic 6-4, 3-6, 6-1.