Hours after news broke that Loughlin and her famed fashion designer husband were among the boldfaced names involved in the alleged scheme, "The View'" co-host, 34, went on Twitter to call out Giannulli.
"To Aunt Becky's husband who talked s--t about ASU - The @McCainInstitute for International Leadership does incredible work w/ students in cooperation with ASU [Arizona State University] and I guarantee those students involved will go on to do great things in the world and didn't have to lie to get there..." McCain wrote.
Loughlin is best known for her role as Aunt Becky on "Full House."
It appears McCain was referring to a 2016 email Mossimo allegedly wrote to William Rick Singer, who is allegedly the mastermind behind one of the largest college admissions scams to ever hit the U.S.
According to Page Six, Mossimo allegedly wrote: “We just met with [our older daughter’s] college counselor this am. I’d like to maybe sit with you after your session with the girls as I have some concerns and want to fully understand the game plan and make sure we have a roadmap for success as it relates to [our daughter] and getting her into a school other than ASU!”
Federal authorities have also charged college coaches and others in a sweeping admissions bribery case, the Associated Press reported Tuesday.
At least 13 people, including Loughlin's husband and fellow actress Felicity Huffman, were arrested Tuesday morning and expected to make their first court appearance later in the day.
A rep for "Fuller House" star Loughlin, who reportedly has been filming a movie in Vancouver, told Fox News that she had no information on the case at this time. A rep for Huffman, who U.S. Attorney Andrew Lelling said in a press conference had been arrested by federal agents, did not return multiple requests for comment. An attorney for Giannulli did not immediately respond to Fox News' request for comment.
The racketeering conspiracy charges were unsealed Tuesday and they include charges against coaches at schools such as Wake Forest University, Georgetown and the University of Southern California. Investigators said the coaches accepted bribes in exchange for admitting students as athletes, regardless of their ability.
According to authorities, parents would pay a predetermined amount to college entrance consultant William Rick Singer who would then give the funds to coaches, SAT or ACT administrators.
The alleged fund amounts ranged from several thousand dollars to $6 million.
The documents alleged that Loughlin and her husband, Giannulli, "agreed to pay bribes totaling $500,000 in exchange for having their two daughters designated as recruits to the USC crew team – despite the fact that they did not participate in crew – thereby facilitating their admission to USC."
Officials claimed to have obtained emails from Loughlin supporting their case.
Loughlin's daughter, the YouTube sensation Olivia Jade, attends USC. It is not immediately clear if Loughlin's other daughter, Isabella, attends the university.
Fox News' Jessica Sager and Sasha Savitsky and The Associated Press contributed to this report.