Chicago White Sox designated hitter Manny Ramirez has left a game against the Detroit Tigers in the eighth inning after being hit on the left wrist by a pitch.

White Sox starting pitcher Freddy Garcia (back) and Tigers slugger Miguel Cabrera (shoulder) also left Tuesday night's game with injuries.

Ramirez, plunked earlier in the game by Justin Verlander, was hit again in the eighth by rookie Robbie Weinhardt. The pitch came close enough to the knob of Ramirez's bat that plate umpire Angel Campos checked with first-base ump Brian Gorman to see if it should be ruled a foul ball.

Ramirez was examined briefly by the Chicago training staff before walking into the dugout. He was replaced by Alejandro De Aza with the White Sox trailing 6-1.