Defending champ and two-time runner- up Novak Djokovic and former champion Andy Roddick were routine first-round winners Tuesday at the U.S. Open.

The second-seeded Djokovic walloped Italian Paolo Lorenzi, 6-1, 6-0, 6-1 during the night session at Arthur Ashe Stadium. It was a repeat performance for the Serbian against Lorenzi, who was ousted in only 73 minutes.

The two players met at the same stage at the Australian Open earlier this year, when Lorenzi won just a pair of games. Djokovic went on to win that title, his fifth at a Grand Slam event.

"It's important for me to try to be as economical as possible with the time I spend on the court, but obviously not underestimating any opponent," Djokovic said. "I played really focused."

The 20th-seeded Roddick, a former world No. 1, handled 21-year-old American qualifier Rhyne Williams 6-3, 6-4, 6-4 at Ashe Stadium. The big-serving Roddick fired 20 aces en route to the second round.

Roddick, who turns 30 Thursday, captured his lone Grand Slam title at the 2003 U.S. Open and was the 2006 runner-up in New York.

"I think the game has changed a lot," Roddick said. "You probably were able to get two feet under you and kind of launching the ball a lot more then. I had a massive serve at 135 mph, and this kid today was hitting them that big. I think the game has gotten significantly better since then."

Fifth-seeded former Australian Open runner-up Jo-Wilfried Tsonga got past Slovak Karol Beck 6-3, 6-1, 7-6 (7-2) in an error-filled match, while sixth- seeded Czech and former Wimbledon runner-up Tomas Berdych handled promising Belgian David Goffin, making his U.S. Open debut, 7-5, 6-3, 6-3. The French Tsonga was a U.S. Open quarterfinalist last year.

Spain's Guillermo Garcia-Lopez upset 10th-seeded Argentine Juan Monaco, 3-6, 1-6, 6-4, 7-6 (8-6), 7-6 (7-3).

Meanwhile, 11th-seeded Spaniard Nicolas Almagro held off Czech veteran Radek Stepanek 6-4, 6-7 (5-7), 6-3, 6-4; 14th-seeded Alexandr Dolgopolov of Ukraine rallied to beat American Jesse Levine, 3-6, 4-6, 6-4, 6-1, 6-2; and 15th- seeded rising Canadian Milos Raonic launched 30 aces in going the distance to stave off game Colombian Santiago Giraldo in five sets, 6-3, 4-6, 3-6, 6-4, 6-4, in 3 hours, 25 minutes. This marked Raonic's first-ever win in the main draw at the U.S. Open.

Raonic overcame 15 double faults.

"A lot of double faults, and it wasn't just one double fault per game," Raonic said. "It was when I double-faulted I double-faulted consistently a couple times in a row, so that made my job a lot more difficult and it gave him a little bit more freedom at the same time."

Also Tuesday, 18th-seeded Swiss Stan Wawrinka overcame Ukrainian Sergiy Stakhovsky 6-7 (6-8), 7-6 (7-2), 6-4, 6-2.

Tall American Sam Querrey, seeded 27th at this fortnight, swatted 21 aces and came from behind to beat Taiwan's Yen-Hsun Lu 6-7 (4-7), 6-4, 6-4, 7-5 in just over three hours.

Cypriot Marcos Baghdatis, who lost in the first round in his three previous trips to the U.S. Open, won a five-setter against Germany's Matthias Bachinger, 6-2, 4-6, 6-4, 6-7 (8-10), 7-6 (7-5).

Also advancing on Day 2 were, No. 31 seed Julien Benneteau of France, Taiwan's Jimmy Wang, Belgian Steve Darcis, Spaniard Pablo Andujar, German Philipp Petzschner, Bernard Tomic, Fabio Fognini, Rogerio Dutra Silva, and Russian- born American Dennis Novikov, who bested 6-foot-8 Pole Jerzy Janowicz 6-2, 7-6 (8-6), 3-6, 6-3. Novikov plays collegiate tennis at UCLA.

Argentina's David Nalbandian withdrew from both singles and doubles on Tuesday due to a chest muscle injury. His place in the singles, scheduled as the third match in Louis Armstrong Stadium on Wednesday against seventh seed and fellow countryman Juan Martin del Potro, will be taken a lucky loser determined in the morning.