David Ortiz hits 400th career home run

Boston Red Sox designated hitter David Ortiz hit his 400th career home run on Wednesday.

Ortiz became the 49th player in major league history to reach the milestone with a leadoff homer to right off young Oakland right-hander A.J. Griffin in the fourth inning, his 22nd of the season.

The 36-year-old slugger has 342 homers since joining the Red Sox in 2003. He hit his first 58 with the Minnesota Twins.

The Red Sox lost the game, 3-2, and were swept by the Athletics for the first time since 2008.