Updated

Tony Parker had 29 points and 13 assists, Tim Duncan had 19 points and eight rebounds, and the San Antonio Spurs handed the Los Angeles Lakers their worst loss of the season, 112-91 on Tuesday night.

Manu Ginobili scored 15 points as the Spurs improved their spot atop the Western Conference with their fourth straight win. They also snapped Los Angeles' four-game winning streak while dominating a meeting of division leaders — albeit with Kobe Bryant sitting out his sixth straight game to rest his bruised shin.

Andrew Bynum had 21 points and seven rebounds for the Lakers, whose Pacific Division lead over the Clippers dwindled to a half-game, although the Lakers hold the tiebreaker. Matt Barnes and Pau Gasol scored 16 points apiece, but with Bryant watching from the bench in a sharp suit, Los Angeles couldn't match the depth of the Spurs, who got at least four points from 10 players.

Just six days after the Kobe-less Lakers jumped to a 26-point lead during a comfortable victory at San Antonio, the Spurs answered by scoring 18 consecutive points during an impressive second-quarter spree.

San Antonio, which had lost three straight to the Lakers, stretched its lead to 23 points in the third quarter — making 30 of 43 shots in the middle quarters — and hung on comfortably for its 15th win in 17 games. Parker particularly decimated Los Angeles' defense, going 14 of 20 against point guards Ramon Sessions and Steve Blake.

The Spurs (44-16) have a half-game lead over Oklahoma City (44-17) for the No. 1 seed in the West.

The two perennial West powers will meet yet again for a rubber match Friday in San Antonio.

Although Bryant says he would be healthy enough to play if the Lakers were in the playoffs now, coach Mike Brown thinks Bryant is unlikely to play Wednesday at Golden State. The NBA scoring leader already has played through several lesser injuries this season, and Brown seems content to allow Bryant to heal for the postseason, even if his absence costs the Lakers a spot in playoff seeding.

San Antonio coach Gregg Popovich agreed with his former assistant's strategy, saying he would choose health over playoff position. Popovich has rested his veteran core down the stretch, but everybody was active against the Lakers — and everybody contributed to a blowout win.

Bryant's absence had inspired strong performances from the Lakers over the past week, but the Spurs had little trouble with Los Angeles' reconfigured lineup. San Antonio took control with a 24-4 run in the second quarter, blowing open a tight game with opportunistic defense and relentless fast breaks.

Six players scored during the 18-0 portion of the run, with Danny Green hitting consecutive 3-pointers along the way. The Lakers committed seven turnovers in the second quarter, while the Spurs made 17 of 24 shots to take a 63-47 halftime lead.

NOTES: The Spurs have 19 road wins, matching Oklahoma City for the most in the West. Chicago leads the NBA with 22. ... Devin Ebanks had nine points in his 10th start of the season for Los Angeles, his sixth straight in Bryant's place. The second-year pro has played in just 20 games this season. ... Fans near courtside included Denzel Washington, Charlize Theron, Justin Bieber and Selena Gomez, Salma Hayek, Kat Dennings and former Angels 3B Doug DeCinces.