Third baseman Pablo Sandoval has left Boston's game against Seattle with a bruised right elbow.
Sandoval homered in his first at-bat Saturday, and then was hit by Felix Hernandez with his first pitch leading off the third.
Sandoval was attended to by a team trainer for a while, but stayed in the game. He was replaced by Josh Rutledge in the lineup at the beginning of the fourth.
Rutledge went into the game at second base and Brock Holt moved to third.
The Red Sox led 10-2 when Sandoval exited.