Denver, CO (SportsNetwork.com) - Matt Kemp had three hits, four RBI and three runs scored as the San Diego Padres defeated the Colorado Rockies 14-3 in the opener of a four-game set.

Derek Norris posted three hits, three runs scored and an RBI and Wil Myers added two hits a trio of runs scored and an RBI for the Padres, who have won five of their last six games.

Odrisamer Despaigne (2-0) allowed two runs on six hits and two walks with five strikeouts over 6 2/3 innings to earn the win.

"He's got good stuff and keeps hitters off balanced," San Diego's Clint Barmes said.

Jorge De La Rosa (0-1), who was activated from the disabled list prior to the game, was rocked for nine runs -- seven earned -- on nine hits and a walk over two frames for Colorado, which has dropped four straight games.

"I was trying to throw as hard as I can but you can't make outs if you don't have command," De La Rosa said.

Myers singled to lead off the game and Norris followed with a double before Kemp brought them both home with a two-bagger to right center. Justin Upton singled and Jedd Gyorko doubled two batters later to plate Kemp. Yonder Alonso pushed across Upton and Gyorko with a single to right center.

Kemp tallied an RBI single in the second, Will Middlebrooks launched a two-run triple to center and Alonso lifted a sacrifice fly to make it 9-0.

Colorado got two runs back in the fourth on RBI singles by Justin Morneau and Rafael Ynoa, but San Diego plated five more runs in the fifth.

Myers recorded an RBI single, Norris launched a run-scoring double to right, Kemp slapped an RBI single to left center and Venable's two-run blast made it 14-2.

Charlie Blackmon's RBI triple in the ninth capped the scoring.

Game Notes

Kemp has 13 RBI on the season ... The Rockies were 9-for-12 with runners in scoring position, while Colorado finished 2-for-6 ... Despaigne's ERA sits at 1.47.