The San Francisco 49ers' quest for a perfect season ended Sunday, and they just got more bad news.

Wide receiver Deebo Samuel will miss at least the next two games with a hairline fracture in his shoulder, the team said Saturday.

Samuel left Sunday's loss to the Cleveland Browns with the injury and did not return. 

Christian McCaffrey also left with an oblique injury, but he's not expected to miss much time, if any.

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Deebo Samuel vs the Eagles

Deebo Samuel of the San Francisco 49ers stands on the sidelines during the second quarter of the NFC championship game against the Philadelphia Eagles at Lincoln Financial Field Jan. 29, 2023, in Philadelphia. (Kevin Sabitus/Getty Images)

Head coach Kyle Shanahan told reporters Samuel won't return until after the team's bye week, so the receiver will be out until at least mid-November.

The 49ers had won 15 consecutive regular season games dating to last season. 

The Browns were without Deshaun Watson in the win. He was also dealing with a shoulder injury.

Samuel missed four games last year with a hamstring and ankle injury.

Deebo Samuel against Cards

Deebo Samuel of the San Francisco 49ers lines up during a game against the Arizona Cardinals at Levi's Stadium Oct. 1, 2023, in Santa Clara, Calif. (Michael Owens/Getty Images)

The Niners face the Minnesota Vikings Monday night before taking on the Cincinnati Bengals in Week 8. San Fran has a Week 9 bye

After a campaign that earned him his first first-team All-Pro nod, Samuel had somewhat of a down season in 2022, which was plagued by injuries. He had just 632 receiving yards after racking up 1,405 the previous year. His 18.2 yards per reception were a league-high in 2021.

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Deebo Samuel vs the Cowboys

San Francisco 49ers wide receiver Deebo Samuel walks off the field after warmups before an NFC divisional playoff game against the Dallas Cowboys at Levi's Stadium in Santa Clara, Calif. (Bob Kupbens/Icon Sportswire via Getty Images)

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In his first five games this season, Samuel had 20 receptions for 302 yards and a touchdown and 95 rushing yards on 18 carries, one for a score.