The Senate confirmed Kristen Clarke as the first Black woman to run the Department of Justice’s Civil Rights Division in a 51-48 vote Tuesday afternoon. 

Sen. Susan Collins, R-Maine, voted yes with all Democrats, and Sen. John Kennedy, R-La., did not vote. 

Vice President Kamala Harris ceremonially swore in Clarke as assistant attorney general for civil rights on Tuesday evening. 

The vote came on the anniversary of the death of George Floyd, timing Sen. Majority Leader Chuck Schumer called "particularly poignant and appropriate."

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Clarke previously served in the Justice Department under former President Barack Obama. 

The Civil Rights Division under Clarke is expected to investigate policing throughout the country, already leading civil investigations into the Minneapolis Police Department and a probe in Louisville, Ky., where Breonna Taylor was killed. And as a number of states move to enact voting restrictions, the department is expected to investigate voting laws for discrimination under the Voting Rights Act. 

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Clarke’s confirmation was controversial because of her prolific Twitter use, where she would often launch broadsides against some senators, including Sen. Joe Manchin, D-W. Va., and Sen. Lisa Murkowski, R-Alaska. Clarke also has a history of controversial writings, including a 2020 Newsweek op-ed headlined: "I Prosecuted Police Killings. Defund the Police—But Be Strategic."

Clarke said in a hearing before the Judiciary Committee that she did not actually mean to say police should be defunded in that op-ed.

She has also labeled President Donald Trump's judicial nominees as "white male extremists."

Symone Sanders, senior advisor to Harris, called Clarke's swearing-in a "historic moment." "She is a timeless champion of equal justice. She has done groundbreaking and courageous legal advocacy and enforcement work, in virtually every area of civil rights, including voting rights, religious freedom, gender equity, educational equity, LGBTQ rights, criminal justice reform, immigration rights," she said. 

Sanders shot back against accusations that Clarke was an overtly partisan figure due to her past tweets and writings. "I think it is safe to say from my perspective that there's nothing partisan about protecting the civil rights of the American people. And that's exactly what Kristin Clarke will be doing in this role."

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In her confirmation hearing, Clarke touted work with people of all backgrounds and political affiliations. 

"Our nation is a healthier place when we respect the rights of all communities. In every role I've held, I have worked for and with people of all backgrounds -- regardless of race, national origin, religion and disability status," Clarke wrote. "I've listened deeply to all sides of debates, regardless of political affiliation. There is no substitute to listening and learning in this work, and I pledge to you that I will bring that to the role if confirmed."

For the past five years, she was been working on the nonprofit Lawyers’ committee, which focuses on social justice.