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Having Derek Jeter and Alex Rodriguez in the lineup together for the first time this season did not result in a win for the New York Yankees.

The Yanks hope for a change of fortune on Tuesday night as they play the second contest of a three-game series with the Toronto Blue Jays.

Things seemed to tilting towards New York on Monday night, as they were set to have Jeter in the lineup for only the sixth time this year. The shortstop has had three stints on the disabled list due to various leg ailments and went 0- for-3 with a walk in his first game since Aug. 2.

Manager Joe Girardi is expected to keep his eye on Jeter's health in an effort to keep him healthy for the stretch run. The 39-year-old reported no problems after last night's contest.

"I always feel like I can play," Jeter said. "I haven't talked to (Girardi). My job here is to play, so I'll come here ready to play (Tuesday)."

Rodriguez, meanwhile, hit his 650th career homer, 10 shy of Willie Mays for fourth on baseball's all-time list, but it was a solo shot and New York did little else against Toronto starter R.A. Dickey in a 5-2 loss.

Dickey gave up two runs -- one earned -- on six hits and three walks over 6 1/3 innings of work. Edwin Encarnacion drove in two runs as the Blue Jays picked up their second straight win following a seven-game slide.

Toronto also beat New York for the first time since April 21 at home. The Jays' recent 10-game slide to the Yankees included getting swept last week in four games at the Bronx, where the club is 0-10 this year.

"We want to finish the season strong," Toronto's Jose Reyes said. "Every win from now on is going to be huge."

New York, meanwhile, lost for the third time in four games and sits 4 1/2 games back of the second wild card spot in the American League. It also is 7 1/2 contests back of first place in the AL East.

Phil Hughes remained winless since July 2 after allowing five runs -- three earned thanks to an error by Ichiro Suzuki -- on seven hits and three walks over 4 2/3 innings for the Yankees,

"Every time I feel like I'm making progress ... it seems like I have these kind of hiccups," Hughes said.

Andy Pettitte defeated Toronto's J.A. Happ last Thursday to cap off the four- game sweep in New York and rematches with the left-hander tonight.

Pettitte has won consecutive outings since going winless in five straight starts. He won for the first time since mid-July with a 10-3 decision in Boston on Aug. 16, then bested the Blue Jays with six innings of one-run ball in a 5-3 decision.

The 41-year-old lefty is 9-9 with a 4.26 earned run average in 23 starts this year and has won both of his outings versus the Blue Jays in 2013.

Happ fell to 2-1 with a 5.46 ERA in five career encounters with the Yankees after giving up four runs on three hits and five walks over 5 1/3 innings.

"I just walked two guys in the sixth inning and cost us the ball game," Happ noted. "I felt good making pitches, doing everything I could. I felt good about the way the game was going. Some crazy stuff happened in this game that I'm just not going to talk about."

The 30-year-old is 1-1 with a 5.40 ERA in four games since coming back from injury and 3-3 on the campaign with a 5.10 ERA in 11 starts.