(SportsNetwork.com) - CC Sabathia and the New York Yankees are set to face Justin Masterson and the rival Boston Red Sox Friday night at Fenway Park in the opener of a three-game series.

Both starters enter the game with ERAs north of 5.00. Sabathia is 0-4 with a 5.96 ERA and has not recorded a win in more than a calendar year (April 24, 2014). The left-hander has gone six straight starts without a victory, the longest drought of his career.

Most recently, Sabathia was shelled at home by the New York Mets last week, as he allowed seven runs on nine hits in five innings.

Meanwhile, Masterson brings a 2-0 record into Friday's opener but also a 5.16 ERA. However, seven of his 13 earned runs allowed this season came in his second start against Washington.

The right-hander went seven innings at Camden Yards his last time out and held the potent Baltimore Orioles offense to three runs on seven hits. He has 20 strikeouts and nine walks across 22 2/3 innings so far this season.

The Red Sox began their nine-game homestand by taking two of three from the Toronto Blue Jays this week before getting the day off Thursday.

In Wednesday's series finale, Boston claimed a 4-1 victory behind a rock-solid start from Rick Porcello, who went seven innings and allowed just one run on two hits to go with six strikeouts.

"He was a controlling both sides of the plate," said Red Sox catcher Ryan Hanigan. "That's what we talked about before the game, and it worked out."

Cleanup hitter Hanley Ramirez tied the Red Sox club record with his 10th home run in the month of April.

New York is looking to rebound from a 3-2 loss to Tampa Bay Wednesday night in 13 innings. Prior to that outcome, the Yankees had won three straight and seven of eight games.

Michael Pineda got the start on Wednesday and twirled 5 2/3 innings of two-run ball as he struck out five and walked nobody.

"I thought he threw the ball pretty well," Yankees manager Joe Girardi said of Pineda. "They made him work after the first inning pretty hard and his pitch count got up, but he gave up the two runs and he gave us a great opportunity to win."

Five Yankees relievers then came on and managed to keep Tampa Bay off the scoreboard until the 13th, when Chasen Shreve gave up the go-ahead single to James Loney.

The Red Sox won two of three at Yankee Stadium when these teams met in the season's first month.