Ricardo Ratliffe matched his career best with six blocked shots and Michael Dixon had 15 points with three 3-pointers, helping No. 13 Missouri run Iowa State out of the gym early in an 87-54 rout Saturday night.

Jake Anderson had 20 points for the Cyclones (14-6, 1-4 Big 12), who committed a season-worst 19 turnovers and went 4 for 22 from 3-point range while getting blown out for the first time.

Jamie Vanderbeken threw up a dud with five points after going 13 for 19 from 3-point range the previous two games, and was benched much of the second half. Diante Garrett was held to six points on 3-for-16 shooting.

Missouri (17-3, 3-2) had the game over by halftime, forging a 22-point lead with play dominant enough to overcome its own mistakes, including nine turnovers and 5-for-14 shooting from 3-point range. The Tigers have won six in a row in the series and are 83-21 at home overall.

Iowa State has lost three of four but before this one had been competitive, either leading or tied in the final minute of all but one of its setbacks. The Cyclones were hitting 39 percent from 3-point range before Saturday.

Much of a sellout crowd of 15,061 was on the road midway through the second half as Missouri went to 13-0 at home. The Tigers have led by at least 15 points in all but one of their last nine at home.

Marcus Denmon scored 13 points, Ratliffe and Kim English added 12 apiece and Justin Safford had 11.

Previously, Iowa State's worst halftime deficit was 10 points in a one-point loss at Nebraska on Jan. 8.

Missouri shrugged off foul trouble that limited Justin Safford and Phil Pressey to 4 minutes apiece in the run-and-gun first half. The 6-foot-9 Ratliffe had two impressive plays, closing ground fast to block Melvin Ejim's fast-break layup attempt and driving the length of the court for a layup.

Iowa State was even off on free throw shooting, missing three of eight in the first half to equal its total misses from the previous three games. The Cyclones were scoreless for more than 4 minutes while Missouri scored eight straight points for a 28-16 lead.