World No. 4 Andy Murray was a quarterfinal upset victim Friday, while three-time runner-up David Ferrer fought his way into the semifinals at the $2.135 million Barcelona Open.

Rising Canadian slugger Milos Raonic fired 14 aces and stunned the second- seeded Murray 6-4, 7-6 (7-3) on the red clay at the Real Club de Tenis Barcelona, where Raonic trains year-round. It marked Raonic's first-ever win over a top-four player.

The 21-year-old Raonic has already reached three finals this year, including titles in India and San Jose.

A third-seeded Ferrer, meanwhile, setup a semifinal date with Raonic by outlasting lefthanded seventh-seeded fellow Spaniard Feliciano Lopez 6-7 (4-7), 7-6 (9-7), 6-3. Ferrer lost to Nadal in last year's Barcelona final and the 2008 and 2009 all-Spanish title tilts.

The 2012 Barcelona titlist will claim $398,000.