Valencia, Spain – Top-seeded and defending champion David round winner, while former U.S. Open round match Wednesday at the $1.905 million Valencia Open.
Ferrer won for the second time in two days, this time with a 6-3, 6-3 handling of Canadian qualifier Vasek Pospisil, who surprised American John Isner in the first round here on the indoor hardcourts at Valencia's City of Arts and Sciences.
The world No. 5 Ferrer beat Marcel Granollers in last year's all-Spanish Valencia finale; also captured this event in 2008; and was the runner-up here back in 2005.
Spaniards have won six of the last eight titles in Valencia, an event that was staged on red clay through 2008.
The sixth-seeded del Potro, meanwhile, handled Russian veteran Dmitry Tursunov 6-4, 6-1. The tall Argentine was last week's Vienna runner-up to French star Jo-Wilfried Tsonga, this week's second seed.
In another opening-round bout on Day 3, hot Croat Marin Cilic handled promising Canadian Milos Raonic 6-4, 6-4. Cilic captured his first title of the year last week in St. Petersburg.
The 2011 Valencia titlist will collect $455,000.