The actress and singer, 63, piggybacked off of Hanks' coronavirus update Tuesday night with an Instagram performance of a song she wrote titled "Broken Man."
Wilson, who is still under quarantine with Hanks after reportedly leaving a hospital days ago, appears to be in good spirits as she smiles for the camera before taking a seat in front of two male musicians playing acoustic guitar.
"It don't make it mad / And it don't make it wrong / He's a little bit lost but he's not too far gone / You're trying to change him and you don't know if you can / It takes a hell of a lover to love a broken man," Wilson belts out the song's chorus.
She also urged her nearly 900,000 followers to have compassion for one another during such an unsettling time in the world.
"Broken Man by Rita Wilson - Written with Gary Burr," she captioned the post. "People aren't perfect. Gotta love them flaws and all."
At the end of the four-minute-long video, Wilson stands up and flashes another smile before she ends filming.
A number of Wilson's famous pals responded to the song with praise and well-wishes for a speedy recovery.
"hope you're feeling better," "Real Housewives of Beverly Hills" star Kyle Richards commented with emojis.
"Hey you guys!!" Loren Gold, keyboardist for The Who, wrote.
Rosanna Arquette called Wilson's performance "beautiful."
Hanks does not appear in the video, but Wilson's new tune comes hours after the "A Beautiful Day in the Neighborhood" actor provided an update on the couple's symptoms one week after the couple tested positive for COVID-19.
"Hey folks. Good News: One week after testing Positive, in self-isolation, the symptoms are much the same. No fever but the blahs," Hanks revealed. "Folding the laundry and doing the dishes leads to a nap on the couch."
Hanks then told fans that Wilson had won six straight hands of gin rummy and "leads by 201 points."
"But I have learned not to spread my Vegemite so thick," he said referencing fans' reactions to a previous post showing his generous helping of Vegemite on toast.
"I traveled here with a typewriter, one I used to love. We are all in this together. Flatten the curve," Hanks concluded the post, which showed the typewriter he referenced.
Hanks and Wilson's son Chet also shared a message on Instagram on Tuesday, updating followers on his parents' condition.
The 29-year-old actor said that Hanks and Wilson are out of the hospital, in self-isolation and are "feeling a lot better."
As of Wednesday morning, COVID-19 infections surpassed 198,000 globally and more than 7,900 people worldwide had died.
Fox News' Nate Day and The Associated Press contributed to this report.