On Saturday, it was announced that Markle, 38, had signed a deal with Disney to provide a voiceover for an upcoming project from the studio in exchange for a donation to a non-profit benefiting elephants in Botswana.
"You know, she does voiceovers," Harry could be heard saying to Iger, 68, as the prince pointed to his wife.
"Oh really, I did not know that," Iger said.
"She's really interested," said Harry.
"We'd love to try," Iger responded.
The premiere where they spoke actually served as a partnership between Disney and the royals, as it raised funds for Harry's African wildlife conservation efforts.
Following Harry and Markle's announcement that they'd "step back" from their royal duties, rumors have swirled that the pair will follow in the Obamas' footsteps and sign a production deal, using Hollywood as a medium to promote charitable causes.
“I think they can definitely do it," said Curtis "50 Cent" Jackson in reference to the royal couple working in Hollywood. Jackson has served as a producer for several television shows.