Hollywood's most famous couple is calling it quits.

Angelina Jolie has filed for divorce from Brad Pitt, a lawyer for the actress told the Associated Press.

According to court documents, Jolie filed for divorce from Pitt on Monday, citing irreconcilable differences.

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The actress is seeking physical custody of their six children, with visitation rights for Pitt.

Pitt released a statement to People magazine.

"I am very saddened by this, but what matters most now is the well-being of our kids," he said. "I kindly ask the press to give them the space they deserve during this challenging time."

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A rep for Jolie did not return FOX411's request for comment.

Their children are: 15-year-old Maddox, 12-year-old Pax, 11-year-old Zahara, 10-year-old Shiloh, and 8-year-old twins Knox and Vivienne.

Though together for 12 years, Pitt and Jolie Pitt only wed in August 2014. They married privately in the French hamlet of Correns in Provence.

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It was the second marriage for Pitt, 52, who previously wed Jennifer Aniston, and the third for Jolie Pitt, 41, who was previously married to Billy Bob Thornton and Jonny Lee Miller.

The pair infamously got together on the set of their movie "Mr. and Mrs. Smith" while Pitt was married to actress Jennifer Aniston.

They also starred together in the widely panned 2015 film "In the Heart of the Sea," which Jolie directed, about a couple trying to save their failing marriage.

Jolie, a goodwill ambassador for the United Nations, became an outspoken voice for refugees and various causes in Africa, as well as for breast cancer treatment after undergoing a double mastectomy.

Pitt has been heavily involved in rebuilding New Orleans after the devastation of Hurricane Katrina. He has two films coming out at the end of 2016.

The Associated Press contributed to this report.