Well below normal temperatures, with a potential for record lows, are forecast to continue into Tuesday morning across much of the eastern two-thirds of the country.
Freeze watches, warnings and advisories are in effect throughout the region as chilly temperatures are expected from the Midwest and Great Lakes to the interior Northeast.
Over Mother's Day weekend, parts of interior New England saw as much as six inches of snow.
"No more snowfall but cold air is going to continue to linger across the Midwest, back up into the Northeast," Klotz said Monday. "Particularly on Monday, we're looking at a very cold Arctic air mass hanging over the Great Lakes, hanging over the Midwest."
Morning temperatures on Monday range from the 30's in the Midwest to Great Lakes, but the wind chill has some areas falling down into the 20s. In North Dakota, Fargo feels like 19 degrees on Monday morning.
That cold air over the Plains and Upper Midwest shifts east over the next 24 hours towards the Northeast.
"This airmass then shifts on Tuesday over interior New England, stretching down the Atlantic coast," Klotz said Monday. "We'll see freeze watches, warnings, advisories for the next couple of nights."
According to the National Weather Service's (NWS) Weather Prediction Center, a low-pressure system may bring the chance for thunderstorms to southern New England on Monday.
Behind the system, the WPC said another round of light wintry mixed precipitation or snow is also possible for the Central Appalachians and parts of the interior Northeast behind the system as the cold air over the Midwest arrives.
"Once this system moves on out into Wednesday, we do begin to see temperatures rebound closer to normal," Klotz said. "Across the rest of the country, we're looking at fairly quiet weather."
During the day, widespread temperatures in the 50s and 60s will arrive in much of the region.
"If you're looking forward to feeling like May again, we are going to be warming up here in the next couple of days," Klotz said on "Fox & Friends."
Fox News' Adam Klotz contributed to this report.