Mariano Rivera enters the contest one save shy of tying the all-time record of 601 set by Trevor Hoffman, while CC Sabathia will be trying to become the first Yankee pitcher to post back-to- back 20 win seasons since Tommy John (1978-79).
Sabathia, the first American League pitcher with 19 or more wins in three straight years since Oakland's Dave Stewart won 20 or more from 1987-1990, was denied his 20th win on Saturday in Anaheim, but he pitched well, allowing just a run and eight hits in six innings. He did surrender four walks and fell to 19-8 on the year to go along with a 2.93 earned run average.
Houston's Roy Oswalt (2004-05) is the last major league pitcher to record consecutive 20 win seasons.
Sabathia has beaten the Jays three times this season and is 12-3 lifetime against them with a 2.99 ERA.
New York wasn't able to complete a three-game sweep of the Seattle Mariners on Wednesday, as the Yankees fell, 2-1, in 12 innings. Nick Swisher homered in the loss for the Yankees, who have a 4 1/2-game edge on the Boston Red Sox in the AL East standings.
Toronto, meanwhile, enters tonight's opener on the heels of a thrilling win over the Boston Red Sox on Wednesday. The Jays rallied for three runs in the eighth en route to a 5-4 win at Fenway Park.
"The thing we've shown on a number of occasions," said Toronto manager John Farrell, "is we put some adversity behind us and come and get ready to play a solid game."
Getting the call tonight for Toronto will be righty Dustin McGowan, who will make an emergency start in place of Brett Cecil. Cecil was scratched with a cut finger on his pitching hand hours before the start of Friday's contest.
McGowan has appeared in two games (one start) for the Jays this season and has pitched to a 9.00 ERA without recording a decision.
New York has won 10 of its 15 meetings with the Jays this season.