The 24-year-old Querrey, playing his first tennis since mid-June, doused last week's Vienna titlist Tsonga in 7-6 (7-5), 6-2 fashion on the indoor hardcourts at Valencia's City of Arts and Sciences. The world No. 8 Tsonga is trying to qualify for the season-ending ATP World Tour Finals in London later this month.
In other second-round play, Argentine Juan Monaco mauled Italian Fabio Fognini 6-3, 6-1 and Spaniard Marcel Granollers cooled off last week's St. Petersburg champion Marin Cilic of Croatia in come-from-behind style, 3-6, 6-3, 7-5. Granollers was last year's Valencia runner-up to fellow Spaniard David Ferrer, this week's top seed. Ferrer also titled here in 2008 and was the runner-up in 2005.
Granollers will encounter third-seeded French star Gael Monfils on Friday.
The 2011 Valencia titlist will collect $455,000.