Kyle Lohse pitched five shutout innings in a performance shortened by rain, and the St. Louis Cardinals got solo home runs from Colby Rasmus and Matt Holliday in a 6-2 victory over the Baltimore Orioles on Tuesday night.

It was only the second win in seven games for St. Louis since three-time NL MVP Albert Pujols was placed on the disabled list with a broken left wrist. The Cardinals were off Monday after being swept at home in a three-game series by Toronto.

Lohse (8-4) gave up four hits, walked one and was aided by two double plays. He threw only 69 pitches before a thunderstorm stopped play for 28 minutes with St. Louis ahead 4-0 in the top of the sixth.

That ended Lohse's night, but the bullpen preserved his first win in five starts since May 29.

It was the Cardinals' first regular-season game in Baltimore. The Orioles had hosted every other NL team since the introduction of interleague play in 1997.

J.J. Hardy homered for the Orioles, who trailed 6-0 before scoring twice in the eighth. Nick Markakis went 2 for 4 to extend his hitting streak to 17 games, tying a career high. He's batting .410 during that span.

Orioles rookie Zach Britton (6-6) gave up four runs and seven hits in 5 2-3 innings. The left-hander is 1-5 in his last 10 starts.

Back from extended stays on the disabled list, David Freese and Nick Punto immediately made their presence felt by helping the Cardinals go up 3-0 in the second inning. Freese started the uprising with a one-out infield hit and Rasmus walked before Mark Hamilton, Punto and Ryan Theriot delivered successive two-out RBI singles.

Freese missed 51 games with a broken left hand and Punto sat out 38 games with a right forearm strain. Both were activated from the DL on Monday.

Rasmus connected in the sixth off Britton as the rain began to intensify.

In the seventh, Punto tripled and scored on a sacrifice fly by Jon Jay before Holliday hit his 10th home run of the season, a drive to center off Jason Berken.

After St. Louis reliever Lance Lynn struck out five in two innings, Hardy hit his 11th homer in the eighth off Ryan Franklin. Markakis followed with a single and Adam Jones doubled in a run before Fernando Salas got the final five outs.

NOTES: Orioles RHP Alfredo Simon (strained right hamstring) is expected to come off the 15-day disabled list Tuesday, manager Buck Showalter said. ... Baltimore's Derrek Lee hit a second-inning single and now has 1,899 career hits. ... St. Louis improved to 5-5 against the AL. ... Chris Carpenter, who will start for the Cardinals on Wednesday night, last faced the Orioles in 2002 with Toronto. ... Hardy's 11 homers are four more than Baltimore shortstops totaled from 2008-10. ... Luke Scott robbed Holliday of a second home run with a leaping grab at the left-field wall in the ninth inning.