Columbus, OH (SportsNetwork.com) - Ryan Johansen was credited with the game winner in the shootout, and Columbus recovered from a Pittsburgh rally late in regulation to post a 4-3 victory at Nationwide Arena.
Nick Foligno, Boone Jenner and Jack Johnson scored for the Blue Jackets, who extended their season-high win streak to six games.
Sergei Bobrovsky made 33 saves, then turned away Brandon Sutter in the game's final segment to lock up the win.
"That's a big two points for us," Foligno said. "We've got to make sure we tighten up those 6-on-5s. We've got to find away to be a little better, a little smarter. It's tough against a high-powered team like that."
Kris Letang tallied twice, including the tying marker with less than 11 seconds to play for the Penguins, who also received a goal from Blake Comeau.
Thomas Greiss stopped 24 pucks in 65 minutes of play but allowed two of three Columbus shooters to best him.
Cam Atkinson and Johansen scored on the hosts' first two attempts, while Letang kept the visitors in with a score on the Pens' second try. Foligno's backhander went wide of the net, but Sutter's salvo was turned away to end the contest.
Foligno slammed home a centering feed by Jenner from atop the crease just after the three-minute mark of the first to cap the game's first power play.
The Pens escaped unharmed after Patric Hornqvist and Letang committed minors 1:12 apart early in the second which gave the Jackets 48 seconds of 5-on-3 play.
Craig Adams had a prime chance to put the visitors on the board with 5 1/2 minutes left in the period, but he shot high and wide at a half-open net from the right side as Bobrovsky couldn't scramble fast enough to get into position.
Comeau did pull his club even with 4:54 left, scoring from the outer edge of the left circle on a shot which an unscreened Bobrovsky could have stopped if he was tighter to the near post.
Letang's backhander to finish a 2-on-1 short-handed rush with Adams hit the net at 7:22 of the third period.
Jenner was awarded a penalty shot with 7:55 left in regulation when Pittsburgh's Simon Despres dragged him down on a breakaway, and the former tied the game on a quick wrister.
Johnson's shot from the left circle with 2:11 on the clock put the hosts ahead, and the lead seemed safe until Letang forced overtime when his rip from the left-wing boards beat Bobrovsky to the far side with 10.9 showing.
"We played really well in the third period," Letang said. "We were really after them. We earned that point."
Bobrovsky came up with five more stops to keep his team in it while killing a penalty in the extra session.
Columbus snapped a five-game regular season losing skid to Pittsburgh since the clubs were placed in the Metropolitan Division prior to the start of last season ... The teams meet for the second of four matchups in the Steel City on Feb. 19 ... Penguins captain Sidney Crosby sat out a second straight game with an undisclosed illness which has not been confirmed as mumps ... Prior to the contest, the Penguins recalled forward Bobby Farnham from Wilkes- Barre/Scranton of the AHL.