The tournament followed the ATP rankings for the men's singles seedings Wednesday. It did the same for the women's seedings, with Serena Williams 28th.
Djokovic is having one of the best seasons in tennis history: 57-2 with nine titles, including at Wimbledon and the Australian Open. He's seeking his first championship at Flushing Meadows, where he was runner-up to Nadal in 2010 and to Federer in 2007.
The draw is Thursday. Play starts Monday.