Updated

(SportsNetwork.com) - The Minnesota Twins try to win their third straight game on Wednesday when they continue a three-game set with the Boston Red Sox at Target Field.

Minnesota snapped a lengthy home losing streak to the Red Sox in Tuesday's opener, as Chris Parmelee's two-run homer in the ninth inning lifted the Twins to an 8-6 win.

With Andrew Miller (1-1) on the mound, Kurt Suzuki hit a two-out single to keep the inning alive, and Parmelee followed with a crush over the right field wall for the walk-off win.

"Doesn't matter who does it, but I'm glad for (Parmelee)," said Twins manager Ron Gardenhire. "He's worked really hard."

Eduardo Nunez hit a two-run home run, Brian Dozier drove in two, while Joe Mauer and Suzuki each had an RBI for the Twins, who have won three of their last four overall, but beat the Red Sox for the first time in seven home games.

Ricky Nolasco gave up three runs on six hits over six innings of work in the start for Minnesota. Glen Perkins (1-0) worked a scoreless ninth for the win.

"I just tried to battle," said Nolasco. "They gave me some tough at-bats. That's a tough lineup. They don't give away outs and they make you work."

David Ortiz went 4-for-5 with two home runs and four RBI, Shane Victorino was 3-for-5 with an RBI and two runs scored, and Jonny Gomes hit home a run for the Red Sox, who had won their previous two. Jake Peavy gave up six runs on nine hits in just 4 1/3 innings of work.

Ortiz, who played the first six years of his career with the Twins, continued to be a thorn in the side of his former team, as he now has 47 RBI in 55 games against them and has hit safely in 11 of his 12 games at Target Field with seven homers and 20 RBI.

Trying to slow him down on Wednesday will be righty Kevin Correia, who is 1-4 with a 6.34 ERA on the year. Correia was awful on Thursday in Cleveland, as he surrendered four runs and eight hits with four walks in just 4 1/3 innings.

"I think I made a few too many pitches the first few innings and it just kind of caught up to me in the fifth," said Correia. "I don't feel like I really struggled until the last inning. I threw a few too many pitches early, the first warm day we've had, to get upwards of 90 pitches into the fifth inning, it will take its toll on you. I think the fifth was just a turning point where I could have turned it into a good inning or a bad one, and it just turned the other way."

He is 1-0 with a 4.26 ERA in two games (1 start) against the Red Sox, though.

Getting the call for the Red Sox on Wednesday will be lefty Felix Doubront, who has lost his last three decisions and hasn't won since beating the Baltimore Orioles in his first start of the year back on April 3.

Doubront, though, pitched well last Tuesday against Cincinnati, as he allowed a run and five hits in 5 1/3 innings to lower his ERA to 5.09. He has yet to pitch more than 6 2/3 innings in any of his outings this season.

"We're trying to gain some consistency with him to get deeper into games," Red Sox manager John Farrell said. "Our rotation is going to be critical to us and his contribution is going to be needed."

With a win today the Twins would secure their first series win against the Red Sox at Target Field since the building's initial season in 2010.