The Bills confirmed on their Twitter account that they placed Jackson on injured reserve and claimed Tashard Choice off waivers from Washington. Earlier Wednesday, the NFL Network reported that Jackson, one of the leading rushers in the league this season, had a fractured fibula.
It had already been known that Jackson would miss Sunday's important matchup against the New York Jets because of a right leg injury. He appeared to injure his calf during last Sunday's game vs. Miami.
"This is jus a small bump in the road for me! Lookin 4ward to comin back and finishin the rest of my career in Buff," Jackson wrote on his Twitter account early Wednesday evening.
Jackson entered last week's game against the Dolphins as the NFL's leading rusher, but was held to a just 17 yards on seven carries in the 35-8 loss as the Bills were forced to abandon the run after quickly falling behind.
With 934 yards rushing and 442 receiving yards, Jackson's combined total of 1,376 yards from scrimmage trails only Chicago's Matt Forte, who leads the league with 1,391.
Jackson will be hard for Buffalo to replace.
The Bills claimed Choice off waivers to help, though he has totaled only 82 rushing yards on 34 carries this season, playing six games for Dallas and one for Washington. He had a career-high 472 rushing yards with the Cowboys in 2008, his rookie year.
Additionally, backup C.J. Spiller will likely get more playing time. He has rushed 21 times for 115 yards and a touchdown in 10 games for Buffalo this season.
Their production will be crucial for the Bills, who have lost three in a row and take a 5-5 record into Sunday's matchup with the 5-5 Jets.