WIMBLEDON, England -- Three-time Wimbledon runner-up Andy Roddick was eliminated 7-6 (2), 7-6 (2), 6-4 Friday by Feliciano Lopez in the third round, the biggest upset of the men's tournament so far.

The 44th-ranked Lopez served 28 aces and piled up 57 winners to defeat Roddick on Centre Court, the American's first loss to the Spanish left-hander in eight matches.

"He played an outstanding match," Roddick said. "I feel like he played as complete a match as he's played against me. He served about as well as someone has."

In a surprise on the women's side, second-seeded and 2010 runner-up Vera Zvonareva was knocked out 6-2, 6-3 by 33rd-ranked Tsvetana Pironkova of Bulgaria. The Russian converted only one of seven break points and had 18 unforced errors. Pironkova upset Venus Williams here last year en route to the semifinals.

Williams, a five-time champion, set up a fourth-round rematch against Pironkova by routing Maria Jose Martinez Sanchez 6-0, 6-2 in 1 hour on Court 1.

"Last year, I wasn't on my best game," Williams said. "But this year, I'm really going to look forward to really playing a little bit better than last year. Every now and then we all have bad days, but I'm planning to have a better one this year."

Play was suspended for the day shortly after 7 p.m. local time, except on Centre Court where fourth-seeded Andy Murray defeated Ivan Ljubicic 6-4, 4-6, 6-1, 7-6 (4) under the sliding roof to move into the fourth round in his bid to become the first British men's champion in 75 years.

Murray served for the match at 5-3 in the fourth set but couldn't convert, hitting an errant forehand on the second break point. But, in the tiebreaker, Murray took advantage of errors by the Croatian and ended the match by following up a big serve with an forehand putaway.

In the seventh game of the fourth set, Murray pulled off a trick shot -- hopping in the air near mid-court and flicking the ball between his legs for a cross-court winner. He made a similar shot against Jo-Wilfried Tsonga in the final of the Queen's Club tournament June 13.

Among the unfinished matches was defending champion Rafael Nadal's contest on Court 1 against Gilles Muller of Luxembourg. The top-seeded Spaniard was leading 7-6 (6) when the rain came.

Nadal, who saved two set points on his serve at 6-5 down in games, called for a medical timeout after the tiebreaker. He slipped and fell awkwardly behind the baseline, getting up slowly after losing the ninth point of the tiebreaker. Nadal walked off the grounds later after play was suspended for good.

The eighth-seeded Roddick, who lost to Roger Federer in the finals in 2004, '05 and '09, served 23 aces but also had six double-faults. It's the third time in four years Roddick has lost in the early rounds -- he went out in the second round in 2008 and the fourth last year.

"He played better than I did," Roddick said. "He beat me. It's easier for me to walk out of here with that and move forward with that than '08 where I lost to (Janko) Tipsarevic and I felt like I completely choked or last year where I just kind of had a million opportunities and kind of gave it away. Those are tougher to take now."

Lopez, who reached the Wimbledon quarterfinals in 2005 and 2008, broke Roddick twice and had only seven unforced errors.

The Spaniard had lost to Roddick in all their previous matches, including the Wimbledon tuneup at Queen's Club two weeks ago.

"This was a big win for me," Lopez said. "I played Andy so many times and he always beat me. It was so important for me to win today. Even though he beat me before, to beat him at Wimbledon is the most special. I'm happy to pay him back here on this wonderful court."

Williams had 21 winners and only five unforced errors against Martinez Sanchez. It was a big change from her previous match, when Williams was stretched to three sets and three hours by 40-year-old Kimiko Date-Krumm.

"The other match was three hours of nonstop running, so it felt like a marathon," she said. "I'm feeling good and it's great to be ready for the second week. I'll get a couple of days off to really get things in order."

Earlier, top-ranked Caroline Wozniacki, pursuing another bid for her first Grand Slam title, made only one unforced error in defeating Virginie Razzano 6-1, 6-3 to move into the third round.

The 20-year-old Dane was at the top of her game, downing the 96th-ranked Frenchwoman in 66 minutes in sunny conditions on Court 2 at the All England Club.

Wozniacki, who extended her career record against Razzano to 5-0, took command of the match from the beginning and was never in trouble.

Razzano saved three match points at 5-2 down in the second set and another in the next game before Wozniacki hit a service winner into the corner to close the match.

"I served pretty well today and ... dictated quite a few of the points," she said. "I was happy about the game."

In another early women's match, 2004 champion Maria Sharapova recovered from a slow start to beat 17-year-old British wild card Laura Robson 7-6 (4), 6-3 on Court 1. The Russian trailed 4-1 in the first set, and then 4-2 in the tiebreaker, before taking charge against the former Wimbledon junior champion.

"I started off really slow and she started off really well," Sharapova said. "Quite the opposite of me, I think she was much more aggressive than I was in the beginning. But then I just kind of got my rhythm a little bit and started playing better."

Advancing to the round of 16 was fourth-seeded Victoria Azarenka of Belarus, who defeated No. 25 Daniela Hantuchova 6-3, 3-6, 6-2. Azarenka was up 2-1 in the third set when play was suspended by rain. The match resumed after the roof was closed over Centre Court.

Wozniacki, who will face Jarmila Gajdosova, reached the fourth round at Wimbledon the past two years but has never made it to the quarterfinals. Despite her No. 1 ranking, she has never won a major title, losing at the 2009 U.S. Open to Kim Clijsters in her only Grand Slam final.

Wozniacki leads the tour this year with five titles, but lost in the third round at the French Open to extend her drought at the majors. She is guaranteed to hold onto the No. 1 ranking at least until August.

"I think I deserve to be where I am," Wozniacki said. "I won so many tournaments already, five this year. I'm playing good tennis. I'm young. I'm competitive. My time will come."

Wozniacki was asked about being put on Court 2, rather than Centre Court or Court 1. Five-time champion Serena Williams was asked Thursday why she and sister Venus, a five-time champion, had been scheduled on Court 2 while the top men had played only on the two main courts. The Williams sisters have combined to win nine of the last 11 Wimbledon titles.

"Obviously I think I deserve to play on one of the bigger courts," Wozniacki said. "It's up to the tournament to decide where we're going to play. I just go out there and I try to win. ... If (Serena) can play on Court 2, then I guess I can, too."

Elsewhere Friday, seventh-seeded David Ferrrer beat Ryan Harrison of the United States 6-7 (8), 6-1, 4-6, 6-3, 6-2. The match had been suspended by darkness Thursday night in the fourth set.

In women's play, 2007 runner-up and No. 9-seeded Marion Bartoli beat Lourdes Dominguez Lino 4-6, 7-5, 6-2 to reach the third round. No. 11 Andrea Petkovic was ousted by Russia's Ksenia Pervak, 6-4, 7-6 (2).

Two-time Grand Slam titlist Svetlana Kuznetsova, seeded 12th, was eliminated in the third round by No. 19 Yanina Wickmayer, 4-6, 6-3, 6-4. Advancing to the fourth round was No. 8 Petra Kvitova, who beat Roberta Vinci 6-3, 6-3.