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The State Department has said that Iran should release all "innocent U.S. persons" held in that country "immediately" after Iran's foreign minister claimed Wednesday to have offered a prisoner swap to the Trump administration six months ago.

Javad Zarif told an audience at the Asia Society in New York City that Tehran had not yet received a response from Washington, adding: "If they tell you anything else, they're lying."

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In response, a State Department spokesperson noted that the U.S. "repeatedly" had called for a "humanitarian resolution of these cases."

"The Iranian regime can demonstrate its seriousness regarding consular issues, including Iranians who have been indicted or convicted of criminal violations of US [sic] sanctions laws, by releasing innocent U.S. persons immediately," the spokesperson said. "We call on Iran to free all unjustly detained and missing U.S. persons, including Xiyue Wang, Robert Levinson, Siamak Namazi, and Nizar Zakka, among others."

Iran's Foreign Minister Mohammad Javad Zarif speaks at the Asia Society in New York, Wednesday, April 24, 2019. (AP Photo/Richard Drew)

Zarif didn't specify whom Iran might trade, though he mentioned the case of Nazanin Zaghari-Ratcliffe, a British-Iranian woman detained in Iran for nearly three years. On the other side, he cited U.S. extradition warrants against an Iranian man with a heart condition held in Germany for trying to buy spare parts for civilian airplanes, and against an Iranian woman imprisoned in Australia for three years who was the translator in a purchase of equipment for Iranian broadcasting. He did not name either of them.

As foreign minister, Zarif said, he could involve himself only on humanitarian grounds and where there is a possibility of a prisoner exchange, which he did once with the United States in January 2016.

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"We believe their charges are phony," he said of Iranians held in the U.S. "The United States believes the charges against these people in Iran are phony."

"And I put this offer on the table publicly now: Exchange them," he said. "Let's discuss them. Let's have an exchange. I'm ready to do it, and I have authority to do it."

Four Americans are known to be held in Iran. Wang, a Chinese-American graduate student, was sentenced to 10 years in prison in July 2017 for allegedly "infiltrating" the country while doing doctoral research on Iran's Qajar dynasty.

Namazi and his octogenarian father, Baquer, a former representative for the U.N. children's agency UNICEF who served as governor of Iran's oil-rich Khuzestan province under the U.S.-backed shah, were detained in 2015 and 2016, respectively, and have been serving 10-year sentences on espionage charges.

Zakka, a U.S. permanent resident from Lebanon who advocated for Internet freedom and has done work for the U.S. government, was detained in 2015 and sentenced to 10 years on espionage-related charges.

Levinson, a former FBI agent who vanished in 2007 while on an unauthorized CIA mission in Iran, remains missing. Iran has said Levinson is not in the country and it had no further information about him, though his family has held Tehran responsible for his disappearance.

Others held by Iran include Iranian-American art dealer Karan Vafadari and his Iranian wife, Afarin Neyssari, who were arrested in July 2016 and received 27-year and 16-year prison sentences, respectively.

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Last month, former U.S. Navy cook Michael R. White from Imperial Beach, Calif., was sentenced to 10 years in prison in Iran, becoming the first American known to be imprisoned there since Trump took office. Washington-based lawyer Mark Zaid told The Associated Press that White was convicted of insulting Iran's supreme leader and posting private information online, but information surrounding the case remained vague.

Iranian-American Robin Shahini was released on bail in 2017 after staging a hunger strike while serving an 18-year prison sentence for "collaboration with a hostile government." Shahini has since returned to America and is now suing Iran in U.S. federal court.

Fox News' Rich Edson and The Associated Press contributed to this report.