Quick, who has been selected to represent the U.S. in Vancouver next month, stood tall against San Jose's dangerous offense to lift the Kings (25-15-3) to their third straight win.
Los Angeles built a 6-0 advantage behind six different scorers -- Michal Handzus, Oscar Moller, Anze Kopitar, Ryan Smyth, Wayne Simmonds and Scott Parse -- and that proved more than enough to snap the Sharks' eight-game winning streak.
Tied with the Chicago Blackhawks with a league-leading 61 points, the Sharks (27-9-7) dominated the puck and out-shot the Kings 47-20 but could not capitalize on their possession.
Douglas Murray and Patrick Marleau scored in the third to break up a shutout for Quick.
(Writing by Jahmal Corner in Los Angeles; Editing by Nick Mulvenney)