MEMPHIS, Tennessee (AP) – Fourth-seeded Tommy Haas of Germany lost to Belgium's Xavier Malisse 6-4, 3-6, 6-4 Wednesday in the opening round of the Regions Morgan Keegan Championships.
Haas, a three-time winner in Memphis, struggled with his service game, putting 59 percent of his first serves in play and committing eight double faults.
Czech Radek Stepanek, the No. 3 seed, lost to Ernests Gulbis of Latvia 7-6 (5), 7-5.
The elimination of Stepanek and Haas, coupled with No. 2 seed Fernando Verdasco of Spain losing Tuesday, leaves only No. 1 Andy Roddick standing among the top four seeds.
Roddick, who lost to Verdasco in last week's final at the SAP Open, was set to open play Wednesday night against fellow-American James Blake .
In other matches, sixth seed John Isner and Sam Querrey, seeded eighth, won their matches. Isner was pushed to three sets by Jarkko Nieminen of Finland in a 6-7 (3), 6-4, 6-4 victory, while Querrey beat fellow American Rajeev Ram 6-2, 6-3.
In the Cellular South Cup, the women's draw of the tournament, second-seeded Melanie Oudin of the United States defeated countrywoman Lilia Osterloh 6-2, 6-1, while No. 3 Kaia Kanepi of Estonia and Petra Kvitova, the fifth seed, also won.
Kanepi dropped the first set to Nicole Vaidisova of the Czech Republic before rallying for a 4-6, 6-1, 6-3 victory. Kvitova of the Czech Republic was a straight-set winner over Michaella Krajicek of the Netherlands, 6-4, 7-5.
Seventh-seeded Vania King of the United States lost to qualifier Sophia Arvidsson of Sweden 3-6, 6-4, 6-2.
Top-seeded Maria Sharapova will face American Bethanie Mattek-Sands on the stadium court Wednesday night following the Roddick-Blake match.