Chelsea Handler inserted herself into the Brad Pitt-Angelina Jolie divorce news, labeling Jolie a "f---ing lunatic."

The comedian, who is good friends with Brad Pitt's ex-wife Jennifer Aniston, weighed in on rumors that Pitt smokes a lot of marijuana.

"There are rumors that part of problem was that Brad was allegedly drinking and smoking too much weed. I wonder why he needed to self-medicate,” Handler said on her Netflix show "Chelsea." "Maybe because he could have been spending the last 12 years at Lake Como, hanging out with George Clooney and Matt Damon, instead of being stuck in a house with 85 kids speaking 15 different languages."

She quickly added, "Oh yeah — because he married a f---ing lunatic, that’s why."

This isn't the first time Handler has had less-than kind words for Jolie. In a 2010 comedy routine she called the actress a "homewrecker."

In 2013, she called Jolie a "demon" on "Watch What Happens Live."

"It has nothing to do with Jennifer [Aniston]. As a woman, I know when you see somebody walking across the room that’s a bad girl. I just don’t like Angelina Jolie. I don’t think she’s a girl’s girl. I like girl’s girls!"

Handler promised to "respect their privacy during this very difficult time," saying it would be the last time she spoke of the split... on TV.

"You can follow me on Twitter," she teased.

Jolie filed for divorce from Pitt Monday citing irreconcilable differences. Pitt and Jolie infamously met on the set of their 2004 film "Mr. & Mrs. Smith" while Pitt was still married to Aniston.