The initiative, led by Decriminalize Denver, a movement focused on making the mushrooms legal, will appear on municipal election ballots on Tuesday. That comes after the group received almost double the number of signatures required in favor of the push earlier this year.
The measure would make the personal use and possession of psilocybin mushrooms by those 21 years of age or older Denver's "lowest law-enforcement priority," according to the measure's language. It would not legalize psilocybin or permit its sale by Denver's cannabis businesses.
Psilocybin, often referred to as "magic mushrooms," is a "hallucinogenic chemical obtained from certain types of fresh and dried mushrooms." Federally illegal in the U.S. since 1968, psilocybin is categorized by the Drug Enforcement Administration (DEA) under "Schedule I," along with drugs like heroin, marijuana and LSD.
The government states that Schedule I drugs have "no currently accepted medical use and a high potential for abuse."
Medical researchers have found the substance can be used to help treat anxiety and depression in cancer patients. Those studies were small and closely supervised but the preliminary results gave researchers hope that psychedelic drugs could be used to treat cancer, anxiety and post-traumatic stress disorder.
Denver Mayor Michael Hancock and District Attorney Beth McCann have both publicly opposed the proposal. McCann's office handles all criminal charges in Denver.
Between 2016 and 2018, her office referred only 11 of the more than 9,000 drug cases involving psilocybin for possible prosecution. Prosecutors filed charges of possession with intent to manufacture or distribute in three of those cases.
The Associated Press contributed to this report.